Rhodiola Rosea root extract supplement health benefit, side effects, safety, and risks, dosage, drug interactions – Rhodiola is also known as Golden Root, Roseroot, and Aaron’s Rod
Does it have an influence on adhd, adrenal fatigue, anxiety, blood pressure, brain fog, cancer, cortisol, depression, energy, fatigue, libido, memory, menopause, memory, neurotransmitters, stress, testosterone, thyroid, and weight loss?

March 1 2017

Rhodiola rosea herb is traditionally used in Eastern Europe and Asia to stimulate the nervous system, enhance physical and mental performance, treat fatigue, psychological stress and depression. This herb became popular in the late 1990s in the United States following an article in Newsweek magazine promoting its various health benefits including mood enhancement and energy boosting.

Where does the herb grow?
Rhodiola is a plant that grows in high altitude cold regions of the world such as the Arctic, the mountains of Central Asia, the Rocky Mountains, and mountainous parts of Europe, such as the Alps, Pyrenees, Carpathian Mountains, Scandinavia, Iceland, Great Britain and Ireland. In India, this plant is found in the Himalayan region.

Benefits of rhodiola herbal supplements
Rhodiola rosea supplements are often used to enhance physical and mental performance, increase energy levels, and reduce symptoms of psychological stress and depression. Several compounds in this herb have potent antioxidant abilities. Some products have it combined with ginseng and / or maca and St. John’s wort.

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Rhodiola rosea root combines an extract standardized to 0.8% rosavin

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This is a legendary adaptogenic tonifier that comes from the polar arctic regions of eastern Siberia. Among traditional people it is highly valued as a strengthening tonic to increase physical and mental stamina.

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You will find dozens of rhodiola rosea supplements available over the counter. Some of these products are just plain powder, others are standardized to some of the active components of the herb such as rosavins. Not enough research is available to determine which product or standardized extract is the best option to use. Here is an example of some of these products.

Supplements over the counter
Rhodiola extract 90 mg, standardized to contain at least 4% rosavins
3% Rosavins – 500mg 60 Capsules
Siberian Golden Root 5% Rosavins – 300mg 60 Capsules
3% Rosavins – Bulk Powder – 200 grams
It is also available in liquid and tincture.

Rhodiola side effects, caution, risks, danger, safety, and drug interactions
No major rhodiola side effects have been reported in medical journals. High dosages of this herb may cause increased heart rate and insomnia. Minor cases of nausea or stomach upset could occur.

Does it cause hair loss or growth or headache?
We do not think it influences hair growth but high doses could cause headache. High dosages could also cause insomnia.

Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats.
Phytother Res. 2009. Panossian A, Hovhannisyan A, Gabrielyan E. Swedish Herbal Institute Research and Development, Askloster, Sweden.
The aim of this study was to determine whether Rhodiola rosea SHR-5 extract interacts with warfarin and theophylline when administered concomitantly. Thus, concomitant treatment of rats with theophylline and SHR-5 did not give rise to significant effects on the pharmacokinetics of theophylline. Simultaneous administration of SHR-5 and warfarin did not alter significantly the pharmacokinetics or the anticoagulant activity of warfarin. It is concluded that SHR-5 might be of value in the treatment of patients with mild or moderate depression, and that its interaction with co-administered drugs is likely to be negligible.

Benefits of Rhodiola Rosea herb and results of studies, uses in medicine

Q. I am 22 years old, and my caffeine intake has been very high for most of my life. I recently stopped drinking soda altogether and decided to take on a better, more healthy diet (caffeine / stimulant free for over a month!). I also suffer from depression and anxiety. Caffeine seemed to make my anxiety worse by keeping me awake when my brain really wanted rest. It’s been a month since I stopped drinking coffee and I have less anxiety, but it is still there. Also, due to no caffeine intake, I am not very alert and awake even in my most wakeful moment throughout the day. I bought rhodiola and passion flower extract, and I was wondering if it is safe to take a low dose combination, to lower anxiety and increase wakefulness.
A. Each person responds differently to individuals herbs and combinations, and dosages. It is a good idea to try one at a time before combining. There are other dietary supplements that work better for anxiety such as 5-HTP, GABA, valerian, and theanine.

Rhodiola rosea roots have potent anti-depressant activity by inhibiting MAO A. Rhodiola may enhance the level of serotonin in the brain. If a person has depression, they have many natural options to choose from. Some of these natural herbs or nutrients include 5-HTP, SAM-e, and St. John’s wort.

Which is more potent and effective for depression, rhodiola herb or St. John’s wort?
St. John’s wort has been studied much more and in our opinion work better for depression than rhodiola in most people.

This herb may be helpful in certain cases of dementia since it inhibits MAO B. Other supplements used for dementia include acetyl l carnitine, DMAE, cdp-choline, and vinpocetine.

Fatigue due to stress
Rhodiola herb is a good choice for those with fatigue and stress. Ginseng herb is small dosages works well, too. We suggest not taking high dosages of rhodiola since it may interfere with sleep. Lack of sleep can cause fatigue and reduce your ability to fight stress.

A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
Planta Med. 2009: Panossian AG. Department of Psychology, Uppsala University, Uppsala, Sweden.
The aim of the study was to assess the efficacy of the standardised extract SHR-5 of roots of Rhodiola Rosea L. in the treatment of individuals suffering from stress-related fatigue. A total of 60 individuals were randomised into two groups, one of which received four tablets daily of SHR-5 extract (576 mg extract/day), while a second received four placebo tablets daily. We found that repeated administration of Rhodiola rosea extract SHR-5 exerts an anti-fatigue effect that increases mental performance, particularly the ability to concentrate, and decreases cortisol response to awakening stress in burnout patients with fatigue syndrome.

Rhodiola for stress
Effects of Rhodiola rosea extract on behavioural and physiological alterations induced by chronic mild stress in female rats.
J Psychopharmacol. 2009. Faculty of Pharmacy, University of Camerino, Camerino, Italy.
Rhodiola rosea L. is one of the most popular adaptogen and an antistress plant in European and Asiatic traditional medicine. Our previous studies have confirmed the adaptogenic and antistress properties of a single administration of Rhodiola rosea extract in rats exposed to acute stress. There is increasing evidence that prolonged exposure to stressful life events and depression are both related to significant behavioral, endocrinological and neurobiological changes in human and animal subjects. The aim of this study was to determine whether chronic treatment with a hydroalcoholic Rhodiola rosea extract standardized in 3% rosavin and 1% salidroside can prevent alterations induced in female rats following 6 weeks of a chronic mild stress procedure. Our findings strongly showed that chronic administration of Rhodiola rosea extract results in potent inhibition of the behavioral and physiological changes induced by chronic exposure to mild stressors.

Physical performance
Effect of cryopowder Rhodiola rosae on cardiorespiratory parameters and physical performance of humans
Aviakosm Ekolog Med. 2009;
Seven-hour continuous physical loading test (bicycle ergometry) was used to assess effects of Rhodiola rosae (cryopowder) on the human cardiorespiratory system. Comparing with the control, the preparation facilitated activation of the energy-supplying mechanisms in human organism during physical work. In addition, it increased efficiency of the cardiovascular and respiration systems and prevented fatigue growth. The medical herb powder demonstrated explicitly the protective action and can be recommended for use in extreme conditions.

Biochemical effects
Neurological, brain effect of rhodiola
In rodents, rhodiola rosea promoted the proliferation and differentiation of neural stem cells in the hippocampus of depressive rats, and may play a role in saving injured neurons of the hippocampus.

Rhodiola herbal extract as anti inflammatory agent
In vitro inhibitory effects was evaluated against the enzymes relating to inflammation. The enzymes include cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Phospholipase A(2) (PLA(2)). The extract showed varying inhibitory activities against these enzymes depending on the concentrations. A potent inhibition was observed against Cox-2 and PLA(2).

Composition and information
Rhodiola rosea herb contains a variety of compounds including rosavins which include rosavin, rosarin, and rosin. Additional chemicals include salidroside, rhodioloside and tyrosol. There are hundreds of different rhodiola products on the market with different extract potencies. It is difficult to predict which product you will respond to best unless you try it.

What are the active ingredients in rhodiola rosea herb? Is the term rosavins the same as rosavin?
The active ingredients in this herb are rosavin, rosin and rosarin (collectively called rosavins); rosiridin and salidroside. The term rosavins includes three active compounds rosavin, rosin and rosarin.